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Bystolic vs Metoprolol

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Bystolic vs Metoprolol. Beta blockers are a class of drugs that work by blocking the effects of adrenaline on the heart. They are commonly used to treat high blood pressure, heart failure, and other cardiovascular conditions. In this article, we will compare two beta blockers, Bystolic and Metoprolol, and discuss their similarities and differences.

What is Bystolic?

Bystolic is a brand-name beta blocker that contains the active ingredient nebivolol. It works by blocking the beta-1 receptors in the heart, which reduces the heart rate and the force of contractions. Bystolic is primarily used for treating high blood pressure and is available in tablet form.

What is Metoprolol?

Metoprolol is another brand-name beta blocker that contains the active ingredient metoprolol tartrate or metoprolol succinate. Like Bystolic, it blocks the beta-1 receptors in the heart to reduce the heart rate and force of contractions.

Metoprolol is used for treating high blood pressure, angina, and other cardiovascular conditions. It is also available in tablet, injection, and extended-release capsule form.

Comparing Bystolic vs Metoprolol

When comparing Bystolic and Metoprolol, it is important to consider their efficacy, safety profile, side effect profile, contraindications and precautions, and cost.


In terms of efficacy, both drugs are effective in lowering blood pressure and reducing the risk of cardiovascular events. However, some studies have suggested that Bystolic may be more effective at reducing blood pressure compared to Metoprolol.


Both drugs have a similar safety profile, but Bystolic may have a lower risk of causing side effects such as fatigue, dizziness, and sexual dysfunction. Metoprolol may be more likely to cause bronchospasm in patients with asthma or chronic obstructive pulmonary disease (COPD).

Contraindication and Precautions

In terms of contraindications and precautions, Bystolic is contraindicated in patients with severe liver impairment, while Metoprolol should be used with caution in patients with a history of heart failure. Patients with severe bradycardia or heart block should avoid using them.


Finally, when it comes to cost, Bystolic is generally more expensive compared to Metoprolol. The average  price for Bystolic is $210.75 for 30, 10MG Table. For Metoprolol, it costs around  $18 for a supply of 30 tablets.

Both drugs are available in generic form, which can significantly reduce their cost.

Bottom Line

In summary, both Bystolic and Metoprolol are effective beta blockers that are commonly used to treat high blood pressure and other cardiovascular conditions. While they have similar efficacy and safety profiles, there are some differences in their side effect profile, contraindications and precautions, and cost.

Your healthcare provider can help you determine which medication may be more appropriate for your specific medical condition.

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